MOTO'S CV

Motohiro Kobayashi, M.D., Ph.D.
Assistant Professor
Department of Molecular Pathology
Shinshu University Graduate School of Medicine
3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan

Motohiro Kobayashi is a Specialist in Pathology certified by the Japanese Society of Pathology.
His research focus is on mucosal immune response, particularly lymphocyte homing, in chronic inflammatory gastrointestinal diseases.
He also was a member of the duo CALL.

Education:
1990/03: Graduated from Nagano Prefectural Matsumoto Fukashi High School
1997/03: MD, Showa University School of Medicine
2001/03: PhD, Shinshu University Graduate School of Medicine

Postdoctral Training:
2001/04 - 2003/03: Resident, Department of Laboratory Medicine, Shinshu University Hospital
2003/10 - 2005/09: Visiting Scientist, Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA

Academic Positions:
2003/04 - 2007/03: Instructor, Department of Molecular Pathology, Shinshu University Graduate School of Medicine
2007/04 - 0000/00: Assistant Professor, Department of Molecular Pathology, Shinshu University Graduate School of Medicine
2007/04 - 0000/00: Adjunct Assistant Professor, Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University
2010/06 - 0000/00: Adjunct Assistant Professor, Department of Pathology, Showa University School of Medicine
2012/04 - 0000/00: Assistant Professor (Additional Post), Department of Pathobiology, Shinshu University School of Medicine

Hospital Positions:
2000/10 - 2003/09: Pathologist, Showa Inan General Hospital
2000/10 - 2010/03: Pathologist, Nagano Matsushiro General Hospital
2005/10 - 0000/00: Pathologist, Omachi Municipal General Hospital
2010/04 - 0000/00: Pathologist, Nagano Prefectural Kiso Hospital

Licenses and Qualifications:
1997/04: Medical License, Ministry of Health, Labor and Welfare, Japan
2002/08: Specialist in Pathology, Japanese Society of Pathology
2006/04: Supervisory Doctor in Pathology, Japanese Society of Pathology

Professional Affiliations:
Japanese Society of Pathology (Academic Councilor)
Japan Society of Histochemistry and Cytochemistry
Society for Glycobiology
Japanese Society for Immunology
Japanese Society of Inflammation and Regeneration

Awards:
2006: Young Investigator Award, Japanese Society of Pathology

Grants (As a Principal Investigator):
2006 - 2007: Grant-in-Aid for Young Scientists B, Ministry of Education, Culture, Sports, Science and Technology
0000 - 2007: Grant for Encouragement of Research, Hokuto Foundation for Bioscience
2008 - 2009: Grant-in-Aid for Young Scientists B, Ministry of Education, Culture, Sports, Science and Technology
0000 - 2009: Grant-in-Aid to Young Scientists for Exploratory Research, Shinshu University
2010 - 2011: Grant-in-Aid for Young Scientists B, Ministry of Education, Culture, Sports, Science and Technology
2012 - 2014: Grant-in-Aid for Scientific Research C, Japan Society for the Promotion of Science

List of Governmental Grants via KAKEN (Database of Grants-in-Aid for Scientific Research)

List of Publications (Articles in English):
  1. Maruyama M, Kobayashi M*, Sakai Y, Hiraoka N, Oya A, Kageyama S, Tanaka E, Nakayama J, Morohoshi T. Periductal induction of high endothelial venule-like vessels in type 1 autoimmune pancreatitis. Pancreas, in press. IF=2.607 (2010)
  2. Kobayashi M, Hoshino H, Suzawa K, Sakai Y, Nakayama J, Fukuda M. Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases. Semin Immunopathol, in press. [PubMed] IF=5.216 (2010)
  3. Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Moriuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M. Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation. Eur J Pharmacol, in press. [PubMed] IF=2.737 (2010)
  4. Fujiwara M, Kobayashi M*, Hoshino H, Uchimura K, Nakada T, Masumoto J, Sakai Y, Fukuda M, Nakayama J. Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules. J Histochem Cytochem 60: 397-407, 2012. [PubMed] IF=2.381 (2010)
  5. Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, Ueda M, Fukuda MN, Fukuda M, Ishihara K, Nakayama J. Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest 122: 923-934, 2012. [PubMed] IF=14.152 (2010)
  6. Shimojo H, Kobayashi M*, Kamigaito T, Shimojo Y, Fukuda M, Nakayama J. Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer. Prostate 71: 1151-1157, 2011. [PubMed] IF=3.377 (2010)
  7. Kobayashi M*, Mitoma J, Hoshino H, Yu SY, Shimojo Y, Suzawa K, Khoo KH, Fukuda M, Nakayama J. Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma. J Pathol 224: 67-77, 2011. [PubMed] IF=7.274 (2010)
  8. Hoshino H, Kobayashi M*, Mitoma J, Sato Y, Fukuda M, Nakayama J. An integrin α4β7-IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue. J Histochem Cytochem 59: 572-583, 2011. [PubMed] IF=2.381 (2010)
  9. Hoshino H, Tsuchida A, Kametani K, Mori M, Nishizawa T, Suzuki T, Nakamura H, Lee H, Ito Y, Kobayashi M, Masumoto J, Fujita M, Fukuda M, Nakayama J. Membrane-associated activation of cholesterol α-D-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-α-D-glucopyranoside in Helicobacter pylori critical for its survival. J Histochem Cytochem 59: 98-105, 2011. [PubMed] IF=2.381 (2010)
  10. Suzuki A, Kobayashi M, Matsuda K, Matsumoto T, Kawakubo M, Kumazawa S, Koide N, Miyagawa S, Ota H. Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of gCandidatus Helicobacter heilmanniih-induced gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Helicobacter 15: 538-548, 2010. [PubMed] IF=3.109 (2010)
  11. Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, Imai Y, Ito Y, Fukuda M, Kawashima H. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem 285: 40864-40878, 2010. [PubMed] IF=5.328 (2010)
  12. Kobayashi M*, Nakayama J. Immunohistochemical analysis of carbohydrate antigens in chronic inflammatory gastrointestinal diseases. Methods Enzymol 479: 271-289, 2010. [PubMed] IF=1.626 (2010)
  13. Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, Fukuda MN, Fukuda M. Tumor suppressor function of laminin-binding α-dystroglycan requires a distinct β3-N-acetylglucosaminyltransferase. Proc Natl Acad Sci USA 106: 12109-12114, 2009. [PubMed] IF=9.771 (2010)
  14. Kobayashi M*, Fukuda M, Nakayama J. Role of sulfated O-glycans expressed by HEV-like vessels in pathogenesis of chronic inflammatory gastrointestinal diseases. Biol Pharm Bull 32: 774-779, 2009. [PubMed] IF=1.811 (2010)
  15. Kobayashi M, Lee H, Nakayama J, Fukuda M. Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection. Glycobiology 19: 453-461, 2009. [PubMed] IF=3.791 (2010)
  16. Kobayashi M, Lee H, Nakayama J, Fukuda M. Carbohydrate-dependent defense mechanisms against Helicobacter pylori infection. Curr Drug Metab 10: 29-40, 2009. [PubMed] IF=3.896 (2010)
  17. Kobayashi M*, Hoshino H, Masumoto J, Fukushima M, Suzawa K, Kageyama S, Suzuki M, Ohtani H, Fukuda M, Nakayama J. GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis. Inflamm Bowel Dis 15: 697-706, 2009. [PubMed] IF=4.613 (2010)
  18. Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Sagara J, Fukuda M, Nakayama J, Taniguchi S. Role of ASC in the mouse model of Helicobacter pylori infection. J Histochem Cytochem 57: 327-338, 2009. [PubMed] IF=2.381 (2010)
  19. Misawa R, Kobayashi M*, Ito M, Kato M, Uchikawa Y, Takagi S. Primary colonic signet-ring cell carcinoma presenting carcinocythemia: an autopsy case. Case Rep Gastroenterol 2: 301-307, 2008. [PubMed] IF=N/A
  20. Lee H, Wang P, Hoshino H, Ito Y, Kobayashi M, Nakayama J, Seeberger PH, Fukuda M. α1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol α-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth. Glycobiology 18: 549-558, 2008. [PubMed] IF=3.791 (2010)
  21. Kobayashi M*, Fukuda M, Nakayama J. Glycoconjugates and Bacterial Infections: Helicobacter pylori. In: Comprehensive Glycoscience (edited by Kamerling JP), vol 4, pp 439-451, 2007, Elsevier, Oxford. [ScienceDirect] IF=N/A
  22. Harada O, Suga T, Suzuki T, Nakamoto K, Kobayashi M, Nomiyama T, Ohyama C, Fukuda MN, Nakayama J. The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer. Int J Cancer 121: 1072-1078, 2007. [PubMed] IF=4.926 (2010)
  23. Suzawa K, Kobayashi M*, Sakai Y, Hoshino H, Watanabe M, Harada O, Ohtani H, Fukuda M, Nakayama J. Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis. Am J Gastroenterol 102: 1499-1509, 2007. [PubMed] IF=6.882 (2010)
  24. Fukuda M, Kawakubo M, Ito Y, Kobayashi M, Lee H, Nakayama J. Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Methods Enzymol 415: 164-179, 2006. [PubMed] IF=1.626 (2010)
  25. Kobayashi M*. Expression profiling of glycosyltransferases using RT-PCR. Methods Enzymol 416: 129-140, 2006. [PubMed] IF=1.626 (2010)
  26. Kobayashi M, Lee H, Gilmartin TJ, Schaffer L, Head SR, Takaishi S, Wang TC, Nakayama J, Fukuda M. A distinctive set of genes is upregulated during the inflammation-carcinoma sequence in mouse stomach infected by Helicobacter felis. J Histochem Cytochem 55: 263-274, 2007. [PubMed] IF=2.381 (2010)
  27. Lee H, Kobayashi M, Wang P, Nakayama J, Seeberger PH, Fukuda M. Expression cloning of cholesterol α-glucosyltransferase from Helicobacter pylori, a unique enzyme that can be inhibited by natural antibiotic mucin-type O-glycans. Biochem Biophys Res Commun 349: 1235-1241, 2006. [PubMed] IF=2.595 (2010)
  28. Kobayashi M, Mitoma J, Nakamura N, Katsuyama T, Nakayama J, Fukuda M. Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori. Proc Natl Acad Sci USA 101: 17807-17812, 2004. [PubMed] IF=9.771 (2010)
  29. Ohira S, Itoh K, Osada K, Oka K, Suzuki A, Osada R, Kobayashi M, Konishi I. Vulvar Paget's disease with underlying adenocarcinoma simulating breast carcinoma: case report and review of the literature. Int J Gynecol Cancer 14: 1012-1017, 2004. [PubMed] IF=1.558 (2010)
  30. Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J. Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science 305: 1003-1006, 2004. [PubMed] IF=31.364 (2010)
  31. Kobayashi M*, Ito M, Sano K, Honda T, Nakayama J. Pulmonary lymphoepithelioma-like carcinoma: predominant infiltration of tumor-associated cytotoxic T lymphocytes might represent the enhanced tumor immunity. Intern Med 43: 323-326, 2004. [PubMed] IF=1.037 (2010)
  32. Nakayama Y, Horiuchi A, Kumagai T, Kubota S, Kobayashi M, Sano K, Ota H. Discrimination of normal gastric mucosa from Helicobacter pylori gastritis using standard endoscopes and a single observation site: studies in children and young adults. Helicobacter 9: 95-99, 2004. [PubMed] IF=3.109 (2010)
  33. Kobayashi M*, Ito M, Sano K, Koyama M. Granulomatous and cytokine responses to pulmonary Cryptococcus neoformans in two strains of rats. Mycopathologia 151: 121-130, 2001. [PubMed] IF=1.810 (2010)
  34. Sano K, Sakaguchi N, Ito M, Koyama M, Kobayashi M, Hotchi M. Histological diversity of vasculitic lesions in MPO-ANCA-positive autopsy cases. Pathol Int 51: 460-466, 2001. [PubMed] IF=1.481 (2010)
  35. Sano K, Kobayashi M, Sakaguchi N, Ito M, Hotchi M, Matsumoto K. A rat model of hypereosinophilic syndrome. Pathol Int 51: 82-88, 2001. [PubMed] IF=1.481 (2010)
List of Publications via PubMed (NIH National Library of Medicine)

Skills and Interests (Personal):
English Conversation (Pre-1st Grade, Society for Testing English Proficiency), History of Showa Era, Economic Forecasting, Kendo (1st Dan Level, All Japan Kendo Fedaration), Skiing (1st Grade, Ski Association of Japan (SAJ)), SCUBA Diving (Advanced Open Water Diver, Professional Association of Diving Instructors (PADI)), Fishing, Driving (Mazda RX-8), Touring (Honda CB750), Music Performance (Jazz Piano)

My Friends' Website:
Shigeo Sakurai, Toshimitsu Tanaka, Takashi Todoroki, Toshihiko Masuda, Taku Iwasaki, Junya Masumoto, My Father
Last updated on May 14, 2012
Built by Motohiro Kobayashi on March 25, 1996
Special thanks to Ryuen Ito and Kiichiro Kodaira