MOTO'S CV


Motohiro Kobayashi, MD, PhD
Professor
Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui
23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan

Motohiro Kobayashi is a specialist in pathology certified by the Japanese Society of Pathology.
His research focus is on glycopathology, particularly on lymphocyte homing in tumor microenvironment and chronic inflammatory diseases.
He is also a musician and a member of a duo "CALL".

Education:
1990/03: Graduated from Nagano Prefectural Matsumoto Fukashi High School
1997/03: MD, Showa University School of Medicine
2001/03: PhD, Shinshu University Graduate School of Medicine

Postdoctral Training:
2001/04 - 2003/03: Resident, Department of Laboratory Medicine, Shinshu University Hospital
2003/10 - 2005/09: Visiting Investigator, Prof. Minoru Fukudafs Laboratory, Burnham Institute, La Jolla, CA, USA

Academic Positions:
2003/04 - 2007/04: Instructor, Department of Molecular Pathology, Shinshu University Graduate School of Medicine
2007/05 - 2013/06: Assistant Professor, Department of Molecular Pathology, Shinshu University Graduate School of Medicine
2013/07 - 0000/00: Professor, Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui

Hospital Positions:
2000/10 - 2003/09: Pathologist, Showa Inan General Hospital
2000/10 - 2010/03: Pathologist, Nagano Matsushiro General Hospital
2005/10 - 2016/03: Pathologist, Omachi Municipal General Hospital
2010/04 - 2013/05: Pathologist, Nagano Prefectural Kiso Hospital
2013/08 - 0000/00: Pathologist, Fukui Red Cross Hospital

Licenses and Qualifications:
1997/04: Medical License, Ministry of Health, Labor and Welfare
2002/08: Specialist in Pathology, Japanese Society of Pathology
2006/04: Supervisory Doctor in Pathology, Japanese Society of Pathology

Professional Affiliations:
Japanese Society of Pathology (Academic Councilor)
Society for Glycobiology

Awards:
2006: Young Investigator Award, Japanese Society of Pathology
2013: Scientific Research Award, Japanese Society of Pathology

Grants (As a Principal Investigator):
2006 - 2007: Grant-in-Aid for Young Scientists B, Ministry of Education, Culture, Sports, Science and Technology
20070000 - : Grant for Encouragement of Research, Hokuto Foundation for Bioscience
2008 - 2009: Grant-in-Aid for Young Scientists B, Ministry of Education, Culture, Sports, Science and Technology
20090000 - : Grant-in-Aid to Young Scientists for Exploratory Research, Shinshu University
2010 - 2011: Grant-in-Aid for Young Scientists B, Ministry of Education, Culture, Sports, Science and Technology
2012 - 2014: Grant-in-Aid for Scientific Research C, Japan Society for the Promotion of Science
20130000 - : Grant for Encouragement of Research, Hokuto Foundation for Bioscience
2015 - 2017: Grant-in-Aid for Scientific Research C, Japan Society for the Promotion of Science

List of Governmental Grants via KAKEN (Database of Grants-in-Aid for Scientific Research)

List of Publications (Articles in English Only):
  1. Yoshida H, Yoshimura H, Matsuda S, Ryoke T, Kiyoshima T, Kobayashi M, Sano K. The effects of peritumoral bevacizumab injection against oral squamous cell carcinoma in a nude mouse xenograft model: a preliminary study. Oncol Lett 15: 8727-8634, 2018. [PubMed] IF=1.390 (2016)
  2. Kurokawa T, Onuma T, Shinagawa A, Chino Y, Kobayashi M, Yoshida Y. The ideal strategy for cervical cancer screening in Japan: first report of the Fukui Cervical Cancer Study. Cytopathology, in press. [PubMed] IF=2.380 (2016)
  3. Inamura S, Ito H, Shinagawa T, Tsutsumiuchi M, Taga M, Kobayashi M, Yokoyama O. Prostatic stroma inflammation is associated with bladder outlet obstruction in patients with benign prostatic hyperplasia. Prostate, in press. [PubMed] IF=3.820 (2016)
  4. Low S, Hirakawa J, Hoshino H, Uchimura K, Kawashima H, Kobayashi M (corresponding author). Role of MAdCAM-1-expressing high endothelial venule-like vessels in colitis induced in mice lacking sulfotransferases catalyzing L-selectin ligand biosynthesis. J Histochem Cytochem 66: 415-425, 2018. [PubMed] IF=2.511 (2016)
  5. Shinagawa T, Hoshino H, Taga M, Sakai Y, Imamura Y, Yokoyama O, Kobayashi M (corresponding author). Clinicopathological implications to micropapillary bladder urothelial carcinoma of the presence of sialyl Lewis X-decorated mucin 1 in stroma-facing membranes. Urol Oncol 35: 606.e17-606.e23, 2017. [PubMed] IF=3.767 (2016)
  6. Yoshida H, Hoshino H, Imamura Y, Yoshimura H, Sano K, Kobayashi M (corresponding author). Role of sialyl 6-sulfo Lewis X in antitumor immunity against oral squamous cell carcinoma. J Oral Pathol Med 46: 759-765, 2017. [PubMed] IF=2.043 (2016)
  7. Inamura S, Shinagawa T, Hoshino H, Sakai Y, Imamura Y, Yokoyama O, Kobayashi M (corresponding author). Appearance of high endothelial venule-like vessels in benign prostatic hyperplasia is associated with lower urinary tract symptoms. Prostate 77: 794-802, 2017. [PubMed] IF=3.820 (2016)
  8. Low S, Sakai Y, Hoshino H, Hirokawa M, Kawashima H, Higuchi K, Imamura Y, Kobayashi M (corresponding author). High endothelial venule-like vessels and lymphocyte recruitment in diffuse sclerosing variant of papillary thyroid carcinoma. Pathology 48: 666-674, 2016. [PubMed] IF=2.709 (2016)
  9. Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M (corresponding author). Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma. Lab Invest 96: 1246-1255, 2016. [PubMed] IF=4.857 (2016)
  10. Ohtani H, Komeno T, Agatsuma Y, Kobayashi M, Noguchi M, Nakamura N. Follicular dendritic cell-meshwork in angioimmunoblastic T-cell lymphoma is characterized by accumulation of CXCL13+ cells. J Clin Exp Hematop 55: 61-69, 2015. [PubMed] IF=N/A
  11. Wayama MT, Yoshimura H, Ohba S, Yoshida H, Matsuda S, Kobayashi J, Kobayashi M, Gomes Filho JE, Sano K. Diminished progression of periapical lesions with zoledronic acid in ovariectomized rats. J Endodontics 41: 2002-2007, 2015. [PubMed] IF=2.807 (2016)
  12. Kurokawa T, Zha X, Ito H, Aoki Y, Akino H, Kobayashi M, Yokoyama O. Underlying mechanisms of urine storage dysfunction in rats with salt-loading hypertension. Life Sci 141: 8-12, 2015. [PubMed] IF=2.936 (2016)
  13. Nagaoka M, Kobayashi M, Kawai C, Mallanna SK, Duncan SA. Design of a vitronectin-based recombinant protein as a defined substrate for differentiation of human pluripotent stem cells into hepatocyte-like cells. PLoS One 10: e0136350, 2015. [PubMed] IF=2.806 (2016)
  14. Taga M, Hoshino H, Low S, Imamura Y, Ito H, Yokoyama O, Kobayashi M (corresponding author). A potential role for 6-sulfo sialyl Lewis X in metastasis of bladder urothelial carcinoma. Urol Oncol 33: 496.e1-496.e9, 2015. [PubMed] IF=3.767 (2016)
  15. Sakai Y, Kobayashi M (corresponding author). Lymphocyte 'homing' and chronic inflammation. Pathol Int 65: 344-354, 2015. [PubMed] IF=1.465 (2016)
  16. Okamura T, Sakai Y, Hoshino H, Iwaya Y, Tanaka E, Kobayashi M (corresponding author). Superficially located enlarged lymphoid follicles characterise nodular gastritis. Pathology 47: 38-44, 2015. [PubMed] IF=2.709 (2016)
  17. Sakai Y, Hoshino H, Kitazawa R, Kobayashi M (corresponding author). High endothelial venule-like vessels and lymphocyte recruitment in testicular seminoma. Andrology 2: 282-289, 2014. [PubMed] IF=2.427 (2016)
  18. Ito Y, Vela JL, Matsumura F, Hoshino H, Tyznik A, Lee H, Girardi E, Zajonc DM, Liddington R, Kobayashi M, Bao X, Bugaytsova J, Boren T, Jin R, Zong Y, Seeberger PH, Nakayama J, Kronenberg M, Fukuda M. Helicobacter pylori cholesteryl α-glucosides contribute to its pathogenicity and immune response by natural killer T cells. PLoS One 8: e78191, 2013. [PubMed] IF=2.806 (2016)
  19. Iwaya Y, Kobayashi M (corresponding author), Momose M, Hiraoka N, Sakai Y, Akamatsu T, Tanaka E, Ohtani H, Fukuda M, Nakayama J. High levels of FOXP3+ regulatory T cells in gastric MALT lymphoma predicts responsiveness to Helicobacter pylori eradication. Helicobacter 18: 356-362, 2013. [PubMed] IF=3.429 (2016)
  20. Ohya A, Kobayashi M (corresponding author), Sakai Y, Kawashima H, Kageyama S, Nakayama J. Lymphocyte recruitment via high endothelial venules in lymphoid stroma of Warthin's tumor. Pathology 45: 150-154, 2013. [PubMed] IF=2.709 (2016)
  21. Maruyama M, Kobayashi M (corresponding author), Sakai Y, Hiraoka N, Ohya A, Kageyama S, Tanaka E, Nakayama J, Morohoshi T. Periductal induction of high endothelial venule-like vessels in type 1 autoimmune pancreatitis. Pancreas 42: 53-59, 2013. [PubMed] IF=2.967 (2016)
  22. Kobayashi M, Hoshino H, Suzawa K, Sakai Y, Nakayama J, Fukuda M. Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases. Semin Immunopathol 34: 401-413, 2012. [PubMed] IF=5.296 (2016)
  23. Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Moriuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M. Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation. Eur J Pharmacol 685: 15-23, 2012. [PubMed] IF=2.896 (2016)
  24. Fujiwara M, Kobayashi M (corresponding author), Hoshino H, Uchimura K, Nakada T, Masumoto J, Sakai Y, Fukuda M, Nakayama J. Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules. J Histochem Cytochem 60: 397-407, 2012. [PubMed] IF=2.511 (2016)
  25. Karasawa F, Shiota A, Goso Y, Kobayashi M, Sato Y, Masumoto J, Fujiwara M, Yokosawa S, Muraki T, Miyagawa S, Ueda M, Fukuda MN, Fukuda M, Ishihara K, Nakayama J. Essential role of gastric gland mucin in preventing gastric cancer in mice. J Clin Invest 122: 923-934, 2012. [PubMed] IF=12.784 (2016)
  26. Shimojo H, Kobayashi M (corresponding author), Kamigaito T, Shimojo Y, Fukuda M, Nakayama J. Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer. Prostate 71: 1151-1157, 2011. [PubMed] IF=3.820 (2016)
  27. Kobayashi M (corresponding author), Mitoma J, Hoshino H, Yu SY, Shimojo Y, Suzawa K, Khoo KH, Fukuda M, Nakayama J. Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma. J Pathol 224: 67-77, 2011. [PubMed] IF=6.894 (2016)
  28. Hoshino H, Kobayashi M (corresponding author), Mitoma J, Sato Y, Fukuda M, Nakayama J. An integrin α4β7-IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue. J Histochem Cytochem 59: 572-583, 2011. [PubMed] IF=2.511 (2016)
  29. Hoshino H, Tsuchida A, Kametani K, Mori M, Nishizawa T, Suzuki T, Nakamura H, Lee H, Ito Y, Kobayashi M, Masumoto J, Fujita M, Fukuda M, Nakayama J. Membrane-associated activation of cholesterol α-D-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-α-D-glucopyranoside in Helicobacter pylori critical for its survival. J Histochem Cytochem 59: 98-105, 2011. [PubMed] IF=2.511 (2016)
  30. Suzuki A, Kobayashi M, Matsuda K, Matsumoto T, Kawakubo M, Kumazawa S, Koide N, Miyagawa S, Ota H. Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of gCandidatus Helicobacter heilmanniih-induced gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Helicobacter 15: 538-548, 2010. [PubMed] IF=IF=3.429 (2016)
  31. Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, Imai Y, Ito Y, Fukuda M, Kawashima H. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem 285: 40864-40878, 2010. [PubMed] IF=4.125 (2016)
  32. Kobayashi M (corresponding author), Nakayama J. Immunohistochemical analysis of carbohydrate antigens in chronic inflammatory gastrointestinal diseases. Methods Enzymol 479: 271-289, 2010. [PubMed] IF=N/A
  33. Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, Fukuda MN, Fukuda M. Tumor suppressor function of laminin-binding α-dystroglycan requires a distinct β3-N-acetylglucosaminyltransferase. Proc Natl Acad Sci USA 106: 12109-12114, 2009. [PubMed] IF=9.661 (2016)
  34. Kobayashi M (corresponding author), Fukuda M, Nakayama J. Role of sulfated O-glycans expressed by HEV-like vessels in pathogenesis of chronic inflammatory gastrointestinal diseases. Biol Pharm Bull 32: 774-779, 2009. [PubMed] IF=1.683 (2016)
  35. Kobayashi M, Lee H, Nakayama J, Fukuda M. Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection. Glycobiology 19: 453-461, 2009. [PubMed] IF=3.112 (2016)
  36. Kobayashi M, Lee H, Nakayama J, Fukuda M. Carbohydrate-dependent defense mechanisms against Helicobacter pylori infection. Curr Drug Metab 10: 29-40, 2009. [PubMed] IF=2.659 (2016)
  37. Kobayashi M (corresponding author), Hoshino H, Masumoto J, Fukushima M, Suzawa K, Kageyama S, Suzuki M, Ohtani H, Fukuda M, Nakayama J. GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis. Inflamm Bowel Dis 15: 697-706, 2009. [PubMed] IF=4.525 (2016)
  38. Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Sagara J, Fukuda M, Nakayama J, Taniguchi S. Role of ASC in the mouse model of Helicobacter pylori infection. J Histochem Cytochem 57: 327-338, 2009. [PubMed] IF=2.511 (2016)
  39. Misawa R, Kobayashi M (corresponding author), Ito M, Kato M, Uchikawa Y, Takagi S. Primary colonic signet-ring cell carcinoma presenting carcinocythemia: an autopsy case. Case Rep Gastroenterol 2: 301-307, 2008. [PubMed] IF=N/A
  40. Lee H, Wang P, Hoshino H, Ito Y, Kobayashi M, Nakayama J, Seeberger PH, Fukuda M. α1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol α-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth. Glycobiology 18: 549-558, 2008. [PubMed] IF=3.112 (2016)
  41. Harada O, Suga T, Suzuki T, Nakamoto K, Kobayashi M, Nomiyama T, Ohyama C, Fukuda MN, Nakayama J. The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer. Int J Cancer 121: 1072-1078, 2007. [PubMed] IF=6.513 (2016)
  42. Suzawa K, Kobayashi M (corresponding author), Sakai Y, Hoshino H, Watanabe M, Harada O, Ohtani H, Fukuda M, Nakayama J. Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis. Am J Gastroenterol 102: 1499-1509, 2007. [PubMed] IF=9.566 (2016)
  43. Fukuda M, Kawakubo M, Ito Y, Kobayashi M, Lee H, Nakayama J. Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Methods Enzymol 415: 164-179, 2006. [PubMed] IF=N/A
  44. Kobayashi M (corresponding author). Expression profiling of glycosyltransferases using RT-PCR. Methods Enzymol 416: 129-140, 2006. [PubMed] IF=N/A
  45. Kobayashi M, Lee H, Gilmartin TJ, Schaffer L, Head SR, Takaishi S, Wang TC, Nakayama J, Fukuda M. A distinctive set of genes is upregulated during the inflammation-carcinoma sequence in mouse stomach infected by Helicobacter felis. J Histochem Cytochem 55: 263-274, 2007. [PubMed] IF=2.511 (2016)
  46. Lee H, Kobayashi M, Wang P, Nakayama J, Seeberger PH, Fukuda M. Expression cloning of cholesterol α-glucosyltransferase from Helicobacter pylori, a unique enzyme that can be inhibited by natural antibiotic mucin-type O-glycans. Biochem Biophys Res Commun 349: 1235-1241, 2006. [PubMed] IF=2.466 (2016)
  47. Kobayashi M, Mitoma J, Nakamura N, Katsuyama T, Nakayama J, Fukuda M. Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori. Proc Natl Acad Sci USA 101: 17807-17812, 2004. [PubMed] IF=9.661 (2016)
  48. Ohira S, Itoh K, Osada K, Oka K, Suzuki A, Osada R, Kobayashi M, Konishi I. Vulvar Paget's disease with underlying adenocarcinoma simulating breast carcinoma: case report and review of the literature. Int J Gynecol Cancer 14: 1012-1017, 2004. [PubMed] IF=2.369 (2016)
  49. Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J. Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science 305: 1003-1006, 2004. [PubMed] IF=37.205 (2016)
  50. Kobayashi M (corresponding author), Ito M, Sano K, Honda T, Nakayama J. Pulmonary lymphoepithelioma-like carcinoma: predominant infiltration of tumor-associated cytotoxic T lymphocytes might represent the enhanced tumor immunity. Intern Med 43: 323-326, 2004. [PubMed] IF=0.815 (2016)
  51. Nakayama Y, Horiuchi A, Kumagai T, Kubota S, Kobayashi M, Sano K, Ota H. Discrimination of normal gastric mucosa from Helicobacter pylori gastritis using standard endoscopes and a single observation site: studies in children and young adults. Helicobacter 9: 95-99, 2004. [PubMed] IF=3.429 (2016)
  52. Kobayashi M (corresponding author), Ito M, Sano K, Koyama M. Granulomatous and cytokine responses to pulmonary Cryptococcus neoformans in two strains of rats. Mycopathologia 151: 121-130, 2001. [PubMed] IF=1.710 (2016)
  53. Sano K, Sakaguchi N, Ito M, Koyama M, Kobayashi M, Hotchi M. Histological diversity of vasculitic lesions in MPO-ANCA-positive autopsy cases. Pathol Int 51: 460-466, 2001. [PubMed] IF=1.465 (2016)
  54. Sano K, Kobayashi M, Sakaguchi N, Ito M, Hotchi M, Matsumoto K. A rat model of hypereosinophilic syndrome. Pathol Int 51: 82-88, 2001. [PubMed] IF=1.465 (2016)
List of Publications via PubMed (NIH National Library of Medicine)

Skills and Interests (Personal):
English Conversation (Pre-1st Grade, Society for Testing English Proficiency), History of Showa Era, Kendo (1st Dan Level, All Japan Kendo Fedaration), Skiing (1st Grade, Ski Association of Japan (SAJ)), SCUBA Diving (Advanced Open Water Diver, Professional Association of Diving Instructors (PADI)), Fishing, Driving (Toyota 86), Music Performance (Piano, Electric Guitar)

My Friends' Website:
Shigeo Sakurai, Toshimitsu Tanaka, Takashi Todoroki, Taku Iwasaki, My Father

Last updated on May 31, 2018
Built by Motohiro Kobayashi on March 25, 1996
Special thanks to Ryuen Ito and Kiichiro Kodaira